Magnetic Resonance Imaging and Spectroscopy of a Mouse Model of Niemann Pick Type C1 Disease
نویسنده
چکیده
...................................................................................................................... 9 INTRODUCTION........................................................................................................... 11 Dissertation Format ....................................................................................................... 15 PRESENT STUDY.......................................................................................................... 17 In Vivo Assessment Of Neurodegeneration In Niemann-Pick Type C Mice By Quantitative T2 Mapping And Diffusion Tensor Imaging ............................................ 17 Magnetic Resonance Imaging of Brain Atrophy in a Mouse Model of Niemann Pick Type C1 Disease ............................................................................................................ 18 1H Magnetic Resonance Spectroscopy of Neurodegeneration in a Mouse Model of Niemann-Pick Type C1 Disease ................................................................................... 19 Conclusions ................................................................................................................... 21 REFERENCES ................................................................................................................ 22 APPENDIX A: IN VIVO ASSESSMENT OF NEURODEGENERATION IN NIEMANN-PICK TYPE C MICE BY QUANTITATIVE T2 MAPPING AND DIFFUSION TENSOR IMAGING ............................................................................... 27 Copyright Transfer Agreement ..................................................................................... 28 Abstract ......................................................................................................................... 31........................................................................................................................ 3
منابع مشابه
Quantitative magnetic resonance imaging of brain atrophy in a mouse model of Niemann-Pick type C disease
In vivo magnetic resonance imaging (MRI) was used to investigate regional and global brain atrophy in the neurodegenerative Niemann Pick Type C1 (NPC1) disease mouse model. Imaging experiments were conducted with the most commonly studied mouse model of NPC1 disease at early and late disease states. High-resolution in vivo images were acquired at early and late stages of the disease and analyze...
متن کاملLongitudinal Magnetic Resonance Spectroscopy and T2 Measurements in a Mouse Model of Niemann-Pick Type C Disease
Introduction Niemann-Pick Type C (NPC) disease is a rare autosomal recessive neurodegenerative disease which involves impaired transport of intracellular lipids and accumulation of unesterified cholesterol in lysosomes and late endosomes in cells throughout the body [1]. NPC disease symptoms, including progressive ataxia, developmental dystonia, and dementia, often appear in the first decade of...
متن کاملAberrant Promoter Methylation Profile of Niemann-Pick Type C1 Gene in Cardiovascular Disease
Background: The protein of Niemann-pick type C1 (NPC1) gene promotes the egress of cholesterol from late endosomes and lysosomes to other cellular compartments and contributes to a process known as reverse cholesterol transport. This study aimed to examine whether promoter methylation of NPC1 is associated with risk of cardiovascular disease (CVD). Methods: Fifty CVD patients and 50 healthy sub...
متن کاملRole of Diffusion Tensor Imaging in Prognostication and Treatment Monitoring in Niemann-Pick Disease Type C1
Niemann-Pick Disease, type C1 (NPC1) is a rapidly progressive neurodegenerative disorder characterized by cholesterol sequestration within late endosomes and lysosomes, for which no reliable imaging marker exists for prognostication and management. Cerebellar volume deficits are found to correlate with disease severity and diffusion tensor imaging (DTI) of the corpus callosum and brainstem, whi...
متن کاملبررسی یک مورد بیماری Niemann Pick تیپ A
Niemann Pick type A is a very rare hereditary disease with an incidence 1 in 20000-40000 live birth, which is calassified as a shingolipidoses. The disease is marked by the abnormal accumulation of sphingomyelin in most tissues, secondary to sphingomylinase deficiency. The most clinical manifestations are: Splenohepatomegaly–cherry red maculae-neuropathologic findings . This is a ...
متن کامل